Zoledronic acid (ZOL), a third generation aminobisphosphonate (A-BP), is a drug whose potent anticancer activity is limited by its short plasma half-life and rapid uptake and accumulation within bone. We have recently proposed new delivery systems to avoid ZOL accumulation into the bone, thus improving extra-skeletal bioavailability. In this work, we have developed selfassembly PEGylated nanoparticles (NPs) containing ZOL. ZOL-containing NPs showed good technological characteristics and the possibility to be prepared before use. These NPs showed a higher anti-cancer activity, evaluated in nude mice xenografted with prostate cancer PC3 cells, compared with that induced by free ZOL. In addition, NPs induced, in a significant number of animals, the complete remission of tumour xenografts and an increase of survival time.

New self-assembling nanoparticles for bisphosphonate delivery in cancer.

SALZANO, GIUSEPPINA;LA ROTONDA, MARIA IMMACOLATA;DE ROSA, GIUSEPPE
2011

Abstract

Zoledronic acid (ZOL), a third generation aminobisphosphonate (A-BP), is a drug whose potent anticancer activity is limited by its short plasma half-life and rapid uptake and accumulation within bone. We have recently proposed new delivery systems to avoid ZOL accumulation into the bone, thus improving extra-skeletal bioavailability. In this work, we have developed selfassembly PEGylated nanoparticles (NPs) containing ZOL. ZOL-containing NPs showed good technological characteristics and the possibility to be prepared before use. These NPs showed a higher anti-cancer activity, evaluated in nude mice xenografted with prostate cancer PC3 cells, compared with that induced by free ZOL. In addition, NPs induced, in a significant number of animals, the complete remission of tumour xenografts and an increase of survival time.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/510797
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