Hydrogen sulphde it has been considered as a novel gaseous transmitter involved in several physiological and/or pathological processes. Our purpose was to investigate, in a vitro study on human corpus cavernosum tissue, the involvement of H2S in penile erection. Human corpus cavernosum strips (HCC) obtained from male-to-female transsexual undergoing gender reassignment surgery were pre-contracted with phenylephrine (PE, 1μM) in organ baths. The ability of sodium hydrogen sulphide (NaHS, 1μM-10mM (stable donor of H2S) in relaxing these strips with (endothelium dependent) or without endothelium (endothelium independent) was evaluated. In addition, using potassium channels and the Rho/RhoA kinase pathways. For the first time we demonstrate that hydrogen sulphide could be responsible for the physiology of the erection, this pathway might represent a novel therapeutic target for the treatment of erectile dysfunction
HYDROGEN SULPHIDE AS A MEDIATOR OF PENILE ERECTION / Mirone, V.; D'EMMANUELE DI VILLA BIANCA, Roberta; Sorrentino, Raffaella; Fusco, Ferdinando; Longo, N.; Verze, P.; Buonopane, R.; Cirino, G.. - In: EUROPEAN UROLOGY. SUPPLEMENTS. - ISSN 1569-9056. - STAMPA. - 7:(2008), pp. 216-216.
HYDROGEN SULPHIDE AS A MEDIATOR OF PENILE ERECTION
D'EMMANUELE DI VILLA BIANCA, ROBERTA;SORRENTINO, RAFFAELLA;FUSCO, FERDINANDO;G. Cirino
2008
Abstract
Hydrogen sulphde it has been considered as a novel gaseous transmitter involved in several physiological and/or pathological processes. Our purpose was to investigate, in a vitro study on human corpus cavernosum tissue, the involvement of H2S in penile erection. Human corpus cavernosum strips (HCC) obtained from male-to-female transsexual undergoing gender reassignment surgery were pre-contracted with phenylephrine (PE, 1μM) in organ baths. The ability of sodium hydrogen sulphide (NaHS, 1μM-10mM (stable donor of H2S) in relaxing these strips with (endothelium dependent) or without endothelium (endothelium independent) was evaluated. In addition, using potassium channels and the Rho/RhoA kinase pathways. For the first time we demonstrate that hydrogen sulphide could be responsible for the physiology of the erection, this pathway might represent a novel therapeutic target for the treatment of erectile dysfunctionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
