Weinvestigatedtherelationshipofmetabolicsyndrome(MetS)anditsindividualcomponentswithincidenceofmildcognitiveimpairment (MCI) anditsprogressiontodementiainalargelongitudinalItalianpopulation-basedsamplewitha3.5-yearfollow-up.Atotalof2097 participants fromasampleof563265–84-year-oldsubjectsfromtheItalianLongitudinalStudyonAgingwereevaluated.MetSwasdefined according totheThirdAdultsTreatmentPaneloftheNationalCholesterolEducationProgramcriteria.MCI,dementia,Alzheimer’sdisease (AD), andvasculardementia(VaD)wereclassifiedusingcurrentpublishedcriteria.AmongMCIpatientsthosewithMetS(N = 49)hada higher riskofprogressiontodementia(HR,4.40;95%CI,1.30–14.82)comparedwiththosewithoutMetS(N = 72).Afteramultivariate adjustment, theriskinMCIpatientswithMetSapproximatelydoubled(multivariateadjustedHR,7.80,95%CI1.29–47.20)comparedwith those MCIwithoutMetS.Finally,amongnon-cognitivelyimpairedindividualstherewerenosignificantdifferencesinrisksofdeveloping MCI inthosewhowereaffectedbyMetS(N = 608)incomparisonwiththosewithoutMetS(N = 837),aswellasexcludingthoseindividuals with undernutritionorlowinflammatorystatuswithorwithoutundernutrition.Inourpopulation,amongMCIpatientsthepresenceofMetS independently predictedanincreasedriskofprogressiontodementiaover3.5yearsoffollow-up.
Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging / Solfrizzi, V., Scafato, E., Capurso, C., D'Introno, A., Colacicco, A.m., Frisardi, V., Vendemiale, G., Baldereschi, M., Crepaldi, G., Di Carlo, A., Galluzzo, L., Gandin, C., Inzitari, D., Maggi, S., Capurso, A., Panza, F., Italian Longitudinal Study on Aging Working Group: Scafato, E., Galluzzo, L., Gandin, C., Capurso, A., et al.. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - 32:(2011), pp. 1932-1941. [10.1016/j.neurobiolaging.2009.12.012]
Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging.
ABETE, PASQUALE;Cacciatore F;
2011
Abstract
Weinvestigatedtherelationshipofmetabolicsyndrome(MetS)anditsindividualcomponentswithincidenceofmildcognitiveimpairment (MCI) anditsprogressiontodementiainalargelongitudinalItalianpopulation-basedsamplewitha3.5-yearfollow-up.Atotalof2097 participants fromasampleof563265–84-year-oldsubjectsfromtheItalianLongitudinalStudyonAgingwereevaluated.MetSwasdefined according totheThirdAdultsTreatmentPaneloftheNationalCholesterolEducationProgramcriteria.MCI,dementia,Alzheimer’sdisease (AD), andvasculardementia(VaD)wereclassifiedusingcurrentpublishedcriteria.AmongMCIpatientsthosewithMetS(N = 49)hada higher riskofprogressiontodementia(HR,4.40;95%CI,1.30–14.82)comparedwiththosewithoutMetS(N = 72).Afteramultivariate adjustment, theriskinMCIpatientswithMetSapproximatelydoubled(multivariateadjustedHR,7.80,95%CI1.29–47.20)comparedwith those MCIwithoutMetS.Finally,amongnon-cognitivelyimpairedindividualstherewerenosignificantdifferencesinrisksofdeveloping MCI inthosewhowereaffectedbyMetS(N = 608)incomparisonwiththosewithoutMetS(N = 837),aswellasexcludingthoseindividuals with undernutritionorlowinflammatorystatuswithorwithoutundernutrition.Inourpopulation,amongMCIpatientsthepresenceofMetS independently predictedanincreasedriskofprogressiontodementiaover3.5yearsoffollow-up.| File | Dimensione | Formato | |
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