A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.
Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system / D'Errico, Stefano; Oliviero, Giorgia; Amato, Jussara; Borbone, Nicola; Cerullo, V.; Hemminki, A.; Piccialli, Vincenzo; Zaccaria, Sabrina; Mayol, Luciano; Piccialli, Gennaro. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:74(2012), pp. 9310-9312. [10.1039/c2cc33511e]
Synthesis and biological evaluation of unprecedented ring-expanded nucleosides (RENs) containing the imidazo[4,5-d][1,2,6]oxadiazepine ring system.
D'ERRICO, STEFANO;OLIVIERO, GIORGIA;AMATO, JUSSARA;BORBONE, NICOLA;V. Cerullo;PICCIALLI, VINCENZO;ZACCARIA, SABRINA;MAYOL, LUCIANO;PICCIALLI, GENNARO
2012
Abstract
A small collection of ring-expanded nucleosides (RENs), containing the unprecedented bis-alkylated imidazo[4,5-d][1,2,6]oxadiazepine heterocyclic ring system, has been synthesized through a new general approach. Results of preliminary cytotoxicity tests on breast (MCF-7) and lung (A549) cancer cell lines are also reported.| File | Dimensione | Formato | |
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