Chromatin has a complex spatial organization in the cell nucleus that serves vital functional purposes. A variety of chromatin folding conformations has been detected by recent experimental technologies. However, a unified quantitative framework describing spatial chromatin organization is still lacking. Here, we explore a model from polymer physics, the “strings and binders switch”, model to explain the origin and variety of chromatin behaviors that coexist and dynamically change within living cells. This simple model recapitulates the scaling properties of chromatin folding reported experimentally in different cellular systems, the fractal state of chromatin, the processes of domain formation, and looping out.
Complexity of chromatin folding is captured by the Strings and Binders Switch model / M., Barbieri; M., Chotalia; J., Fraser; L. M., Lavitas; J., Dostie; A., Pombo; Nicodemi, Mario. - In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. - ISSN 0027-8424. - 109:(2012), pp. 16173-16178. [10.1073/pnas.1204799109]
Complexity of chromatin folding is captured by the Strings and Binders Switch model
NICODEMI, MARIO
2012
Abstract
Chromatin has a complex spatial organization in the cell nucleus that serves vital functional purposes. A variety of chromatin folding conformations has been detected by recent experimental technologies. However, a unified quantitative framework describing spatial chromatin organization is still lacking. Here, we explore a model from polymer physics, the “strings and binders switch”, model to explain the origin and variety of chromatin behaviors that coexist and dynamically change within living cells. This simple model recapitulates the scaling properties of chromatin folding reported experimentally in different cellular systems, the fractal state of chromatin, the processes of domain formation, and looping out.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
