BACKGROUND. Papillary thyroid carcinoma (PTC) with prominent hobnail features is a recently recognized PTC variant. Its histological hallmark is represented by elongated cells showing high nuclear/cytoplasmic ratio and a hobnail appearance. Only a few cases have been described on histology, showing aggressive clinical and pathological features. Thus, a better patient management might benefit from its early diagnosis on fine needle aspiration (FNA) samples. To date, the FNA cytology of the PTC with prominent hobnail features has not been described yet. CASE. We retrospectively analyzed the FNA taken from a histology-proven PTC with prominent hobnail features. Although a certain degree of morphological overlap with the tall cell variant some peculiar cytological features were observed. In particular, the novel “comet-like” cell feature could represent the cytological counterpart of the histological hobnailing. The V600E BRAF mutation was observed on matched cyto-histological specimen. CONCLUSION. Further investigation is required to validate our diagnostic criteria, as the recognition of PTC with prominent hobnail features on FNA may prospectively enable its pre-operative diagnosis, suggesting a more aggressive neck surgery.

Cytological and Molecular Features of PapillaryThyroid Carcinoma with Prominent Hobnail Features:A Case Report / Bellevicine, Claudio; I., Cozzolino; Malapelle, Umberto; P., Zeppa; Troncone, Giancarlo. - In: ACTA CYTOLOGICA. - ISSN 0001-5547. - STAMPA. - 56:(2012), pp. 560-564. [10.1159/000338395]

Cytological and Molecular Features of PapillaryThyroid Carcinoma with Prominent Hobnail Features:A Case Report

BELLEVICINE, CLAUDIO;MALAPELLE, UMBERTO;TRONCONE, GIANCARLO
2012

Abstract

BACKGROUND. Papillary thyroid carcinoma (PTC) with prominent hobnail features is a recently recognized PTC variant. Its histological hallmark is represented by elongated cells showing high nuclear/cytoplasmic ratio and a hobnail appearance. Only a few cases have been described on histology, showing aggressive clinical and pathological features. Thus, a better patient management might benefit from its early diagnosis on fine needle aspiration (FNA) samples. To date, the FNA cytology of the PTC with prominent hobnail features has not been described yet. CASE. We retrospectively analyzed the FNA taken from a histology-proven PTC with prominent hobnail features. Although a certain degree of morphological overlap with the tall cell variant some peculiar cytological features were observed. In particular, the novel “comet-like” cell feature could represent the cytological counterpart of the histological hobnailing. The V600E BRAF mutation was observed on matched cyto-histological specimen. CONCLUSION. Further investigation is required to validate our diagnostic criteria, as the recognition of PTC with prominent hobnail features on FNA may prospectively enable its pre-operative diagnosis, suggesting a more aggressive neck surgery.
2012
Cytological and Molecular Features of PapillaryThyroid Carcinoma with Prominent Hobnail Features:A Case Report / Bellevicine, Claudio; I., Cozzolino; Malapelle, Umberto; P., Zeppa; Troncone, Giancarlo. - In: ACTA CYTOLOGICA. - ISSN 0001-5547. - STAMPA. - 56:(2012), pp. 560-564. [10.1159/000338395]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/498821
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