Abstract CONTEXT: Bisphenol A, one of the highest-volume chemicals currently available, is known to act as endocrine disruptor, and alters several metabolic functions, including inflammatory pathways. Elevated serum levels of bisphenol A have been found in women with Polycystic Ovary Syndrome (PCOS) and a role of low-grade chronic inflammation has been recently reported in the pathogenesis of this syndrome. Increased spleen volume, a reliable and stable index of chronic inflammation, was strictly associated with the severity of hepatic steatosis in obese subjects, determining the so-called liver-spleen axis. OBJECTIVE: To evaluate the contribution of increased serum bisphenol A levels to low-grade chronic inflammation, hepatic steatosis, and hyperandrogenism in women with PCOS. DESIGN, SETTING AND PARTICIPANTS: Forty lean and overweight/obese premenopausal women with PCOS and 20 healthy age-matched women were consecutively enrolled in a cross-sectional study from 2009 to 2011 at the Federico II University Hospital in Naples . MEASUREMENTS: Bisphenol A , Homeostasis Model Assessment of Insulin Resistance (Ho MA - IR ), laboratory liver tests, Testosterone, Sex Hormone-Binding Globulin (SHBG) , Free Androgen Index ( FAI ), Protein C-Reactive ( CRP ), Interleukin ( IL )-6, and the ultrasound quantification of hepatic steatosis and spleen longitudinal diameter . RESULTS: Independently of body weight, higher bisphenol A levels in PCOS women were associated with higher grades of insulin resistance, hepatic steatosis, FAI, and inflammation, spleen size showing the best correlation. At multivariate analysis spleen size and FAI were the best predictors of bisphenol A (β coefficients 0.379, p=0.007 and 0.343, p=0.014, respectively). CONCLUSIONS: In premenopausal women with PCOS we evidenced an association of serum bisphenol A levels with hepatic steatosis and markers of low-grade inflammation, in particular with spleen size, unravelling the presence of the liver-spleen axis in this syndrome.
BISPHENOL A IN POLYCYSTIC OVARY SYNDROME AND ITS ASSOCIATION WITH LIVER-SPLEEN AXIS / Tarantino, Giovanni; Valentino, Rossella; DI SOMMA, Carolina; D'Esposito, Vittoria; Passaretti, Federica; Pizza, G; Brancato, V; Orio, Francesco; Formisano, Pietro; Colao, Annamaria; Savastano, Silvia. - In: CLINICAL ENDOCRINOLOGY. - ISSN 1365-2265. - 78:3(2013), pp. 447-453. [10.1111/j.1365-2265.2012.04500]
BISPHENOL A IN POLYCYSTIC OVARY SYNDROME AND ITS ASSOCIATION WITH LIVER-SPLEEN AXIS.
TARANTINO, GIOVANNI;VALENTINO, Rossella;DI SOMMA, CAROLINA;D'ESPOSITO, VITTORIA;PASSARETTI, FEDERICA;ORIO, FRANCESCO;FORMISANO, PIETRO;COLAO, ANNAMARIA;SAVASTANO, SILVIA
2013
Abstract
Abstract CONTEXT: Bisphenol A, one of the highest-volume chemicals currently available, is known to act as endocrine disruptor, and alters several metabolic functions, including inflammatory pathways. Elevated serum levels of bisphenol A have been found in women with Polycystic Ovary Syndrome (PCOS) and a role of low-grade chronic inflammation has been recently reported in the pathogenesis of this syndrome. Increased spleen volume, a reliable and stable index of chronic inflammation, was strictly associated with the severity of hepatic steatosis in obese subjects, determining the so-called liver-spleen axis. OBJECTIVE: To evaluate the contribution of increased serum bisphenol A levels to low-grade chronic inflammation, hepatic steatosis, and hyperandrogenism in women with PCOS. DESIGN, SETTING AND PARTICIPANTS: Forty lean and overweight/obese premenopausal women with PCOS and 20 healthy age-matched women were consecutively enrolled in a cross-sectional study from 2009 to 2011 at the Federico II University Hospital in Naples . MEASUREMENTS: Bisphenol A , Homeostasis Model Assessment of Insulin Resistance (Ho MA - IR ), laboratory liver tests, Testosterone, Sex Hormone-Binding Globulin (SHBG) , Free Androgen Index ( FAI ), Protein C-Reactive ( CRP ), Interleukin ( IL )-6, and the ultrasound quantification of hepatic steatosis and spleen longitudinal diameter . RESULTS: Independently of body weight, higher bisphenol A levels in PCOS women were associated with higher grades of insulin resistance, hepatic steatosis, FAI, and inflammation, spleen size showing the best correlation. At multivariate analysis spleen size and FAI were the best predictors of bisphenol A (β coefficients 0.379, p=0.007 and 0.343, p=0.014, respectively). CONCLUSIONS: In premenopausal women with PCOS we evidenced an association of serum bisphenol A levels with hepatic steatosis and markers of low-grade inflammation, in particular with spleen size, unravelling the presence of the liver-spleen axis in this syndrome.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
