Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer / Aviello, Gabriella; Romano, Barbara; Borrelli, Francesca; Capasso, Raffaele; L., Gallo; F., Piscitelli; V. D., Marzo; Izzo, ANGELO ANTONIO. - In: JOURNAL OF MOLECULAR MEDICINE. - ISSN 0946-2716. - 90:(2012), pp. 925-934. [10.1007/s00109-011-0856-x]

Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer.

AVIELLO, GABRIELLA;ROMANO, BARBARA;BORRELLI, FRANCESCA;CAPASSO, RAFFAELE;IZZO, ANGELO ANTONIO
2012

Abstract

Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa, exerts pharmacological actions (antioxidant and intestinal antinflammatory) and mechanisms (inhibition of endocannabinoid enzymatic degradation) potentially beneficial for colon carcinogenesis. Thus, we investigated its possible chemopreventive effect in the model of colon cancer induced by azoxymethane (AOM) in mice. AOM treatment was associated with aberrant crypt foci (ACF, preneoplastic lesions), polyps, and tumour formation, up-regulation of phospho-Akt, iNOS and COX-2 and down-regulation of caspase-3. Cannabidiol-reduced ACF, polyps and tumours and counteracted AOM-induced phospho-Akt and caspase-3 changes. In colorectal carcinoma cell lines, cannabidiol protected DNA from oxidative damage, increased endocannabinoid levels and reduced cell proliferation in a CB(1)-, TRPV1- and PPARγ-antagonists sensitive manner. It is concluded that cannabidiol exerts chemopreventive effect in vivo and reduces cell proliferation through multiple mechanisms.
2012
Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer / Aviello, Gabriella; Romano, Barbara; Borrelli, Francesca; Capasso, Raffaele; L., Gallo; F., Piscitelli; V. D., Marzo; Izzo, ANGELO ANTONIO. - In: JOURNAL OF MOLECULAR MEDICINE. - ISSN 0946-2716. - 90:(2012), pp. 925-934. [10.1007/s00109-011-0856-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/494356
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