Since the majority of high-grade breast cancers express reduced levels of BRCA1 mRNA, we investigated the factors regulating BRCA1 transcription. Factors with specific affinity for the previously identified positive regulatory region (PRR) in the BRCA1 promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series of related factors with affinity for the sense strand of PRR. A subset of the identified factors activated the BRCA1 promoter. Identification of these families of proteins regulating the BRCA1 promoter represents an important step in the comprehension of the mechanisms responsible for breast cancer development.

Regulation of BRCA1 transcription by specific single-stranded DNA binding factors / S., Thakur; T., Nakamura; G., Calin; A., Russo; J. F., Tamburrino; M., Shimizu; G., Baldassarre; S., Battista; Fusco, Alfredo; R. P., Wassell; G., Dubois; H., Alder; C. M., Croce. - In: MOLECULAR AND CELLULAR BIOLOGY. - ISSN 0270-7306. - STAMPA. - 23:(2003), pp. 3774-3787. [10.1128/MCB.23.11.3774-3787.2003]

Regulation of BRCA1 transcription by specific single-stranded DNA binding factors

FUSCO, ALFREDO;
2003

Abstract

Since the majority of high-grade breast cancers express reduced levels of BRCA1 mRNA, we investigated the factors regulating BRCA1 transcription. Factors with specific affinity for the previously identified positive regulatory region (PRR) in the BRCA1 promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series of related factors with affinity for the sense strand of PRR. A subset of the identified factors activated the BRCA1 promoter. Identification of these families of proteins regulating the BRCA1 promoter represents an important step in the comprehension of the mechanisms responsible for breast cancer development.
2003
Regulation of BRCA1 transcription by specific single-stranded DNA binding factors / S., Thakur; T., Nakamura; G., Calin; A., Russo; J. F., Tamburrino; M., Shimizu; G., Baldassarre; S., Battista; Fusco, Alfredo; R. P., Wassell; G., Dubois; H., Alder; C. M., Croce. - In: MOLECULAR AND CELLULAR BIOLOGY. - ISSN 0270-7306. - STAMPA. - 23:(2003), pp. 3774-3787. [10.1128/MCB.23.11.3774-3787.2003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/492059
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