The functionalized polyethylene glycol/polystyrene copolymer support 4 was shown to be suitable for a completely automated synthesis of small- to medium-sized cyclic oligodeoxy-ribonucleotides. Syntheses of the linear precursors were achieved by the phosphoramidite method, whereas the cyclization reactions were based on the phosphotriester chemistry.
Automated synthesis of cyclic oligodeoxyribonucleotides via phosphoramidite method / M. R., Conte; Mayol, Luciano; Montesarchio, Daniela; Piccialli, Gennaro; C., Santacroce. - In: NUCLEOSIDES & NUCLEOTIDES. - ISSN 0732-8311. - ELETTRONICO. - 12:3-4(1993), pp. 351-358. [10.1080/07328319308017831]
Automated synthesis of cyclic oligodeoxyribonucleotides via phosphoramidite method
MAYOL, LUCIANO;MONTESARCHIO, DANIELA;PICCIALLI, GENNARO;
1993
Abstract
The functionalized polyethylene glycol/polystyrene copolymer support 4 was shown to be suitable for a completely automated synthesis of small- to medium-sized cyclic oligodeoxy-ribonucleotides. Syntheses of the linear precursors were achieved by the phosphoramidite method, whereas the cyclization reactions were based on the phosphotriester chemistry.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
