Protected forms of 1,2,3-propanetriol andcis, cis-1,3,5-cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3′-3′ linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3′-phosphoramidites as building blocks, UV thermal denaturation analysis showed the ability of ODNs with this inversion of polarity motif to cooperatively hybridize with duplexes of the type 5′-(Pu)m(Py)n-3′ in an alternate strand recognition approach.

Synthesis and characterization of new 3’-3’ linked oligodeoxyribonucleotides for alternate strand triple helix formation / DE NAPOLI, Lorenzo; DI FABIO, Giovanni; A., Messere; Montesarchio, Daniela; Musumeci, Domenica; Piccialli, Gennaro. - In: TETRAHEDRON. - ISSN 0040-4020. - ELETTRONICO. - 55:32(1999), pp. 9899-9914. [10.1016/S0040-4020(99)00529-3]

Synthesis and characterization of new 3’-3’ linked oligodeoxyribonucleotides for alternate strand triple helix formation

DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA;MUSUMECI, DOMENICA;PICCIALLI, GENNARO
1999

Abstract

Protected forms of 1,2,3-propanetriol andcis, cis-1,3,5-cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3′-3′ linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3′-phosphoramidites as building blocks, UV thermal denaturation analysis showed the ability of ODNs with this inversion of polarity motif to cooperatively hybridize with duplexes of the type 5′-(Pu)m(Py)n-3′ in an alternate strand recognition approach.
1999
Synthesis and characterization of new 3’-3’ linked oligodeoxyribonucleotides for alternate strand triple helix formation / DE NAPOLI, Lorenzo; DI FABIO, Giovanni; A., Messere; Montesarchio, Daniela; Musumeci, Domenica; Piccialli, Gennaro. - In: TETRAHEDRON. - ISSN 0040-4020. - ELETTRONICO. - 55:32(1999), pp. 9899-9914. [10.1016/S0040-4020(99)00529-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/491216
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