Protected forms of 1,2,3-propanetriol andcis, cis-1,3,5-cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3′-3′ linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3′-phosphoramidites as building blocks, UV thermal denaturation analysis showed the ability of ODNs with this inversion of polarity motif to cooperatively hybridize with duplexes of the type 5′-(Pu)m(Py)n-3′ in an alternate strand recognition approach.
Synthesis and characterization of new 3’-3’ linked oligodeoxyribonucleotides for alternate strand triple helix formation / DE NAPOLI, Lorenzo; DI FABIO, Giovanni; A., Messere; Montesarchio, Daniela; Musumeci, Domenica; Piccialli, Gennaro. - In: TETRAHEDRON. - ISSN 0040-4020. - ELETTRONICO. - 55:32(1999), pp. 9899-9914. [10.1016/S0040-4020(99)00529-3]
Synthesis and characterization of new 3’-3’ linked oligodeoxyribonucleotides for alternate strand triple helix formation
DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;MONTESARCHIO, DANIELA;MUSUMECI, DOMENICA;PICCIALLI, GENNARO
1999
Abstract
Protected forms of 1,2,3-propanetriol andcis, cis-1,3,5-cyclohexanetriol were incorporated onto solid supports which were exploited in the solid phase synthesis of 3′-3′ linked oligodeoxyribonucleotides (ODNs), involving only nucleoside 3′-phosphoramidites as building blocks, UV thermal denaturation analysis showed the ability of ODNs with this inversion of polarity motif to cooperatively hybridize with duplexes of the type 5′-(Pu)m(Py)n-3′ in an alternate strand recognition approach.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
