We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.
Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon / Borrelli, F; Izzo, ANGELO ANTONIO; Di Carlo, G; Maffia, P; Russo, A; Maiello, Fm; Capasso, F; Mascolo, NICOLA DOMENICO C. FERDINANDO; Borrelli, Francesca. - In: FITOTERAPIA. - ISSN 1971-551X. - STAMPA. - 73 Suppl 1:(2002), pp. S38-S43. [10.1016/S0367-326X(02)00189-2]
Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon
IZZO, ANGELO ANTONIO;MASCOLO, NICOLA DOMENICO C. FERDINANDO;BORRELLI, FRANCESCA
2002
Abstract
We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
