Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10\%-20\% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.
Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours / M., Santoro; N., Sabino; Y., Ishizaka; T., Ushijima; Carlomagno, Francesca; A., Cerrato; M., Grieco; C., Battaglia; M. L., Martelli; C., Paulin. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - STAMPA. - 68:(1993), pp. 460-464.
Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
CARLOMAGNO, Francesca;
1993
Abstract
Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10\%-20\% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
