Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal urothelium samples. Galectin-1 mRNA levels were highly increased in most high-grade tumors compared with normal bladder or low-grade tumors. Western blot and immuno-histochemical analysis of normal and neoplastic tissues revealed a higher content of galectin-1 in tumors. Galectin-3 mRNA levels were also increased in most tumors compared with normal urothelium, but levels were comparable among tumors of different histological grade. (C) 1999 Wiley-Liss, Inc.
Galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas / L., Cindolo; G., Benvenuto; P., Salvatore; Pero, Raffaela; G., Salvatore; Mirone, Vincenzo; Prezioso, Domenico; V., Altieri; C. B., Bruni; Chiariotti, Lorenzo. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - STAMPA. - 84:(1999), pp. 39-43. [10.1002/(SICI)1097-0215(19990219)84:1<39]
Galectin-1 and galectin-3 expression in human bladder transitional-cell carcinomas
PERO, RAFFAELA;MIRONE, VINCENZO;PREZIOSO, DOMENICO;CHIARIOTTI, LORENZO
1999
Abstract
Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage and in 5 normal urothelium samples. Galectin-1 mRNA levels were highly increased in most high-grade tumors compared with normal bladder or low-grade tumors. Western blot and immuno-histochemical analysis of normal and neoplastic tissues revealed a higher content of galectin-1 in tumors. Galectin-3 mRNA levels were also increased in most tumors compared with normal urothelium, but levels were comparable among tumors of different histological grade. (C) 1999 Wiley-Liss, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
