An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis of migraine has been performed in 70 children. After 4 weeks of medication-free base-line observation, 35 children (group A) received flunarizine (5 mg/day) and 35 (group B) received placebo over a 12-week period. After a 4-week washout they crossed treatments for another 12 weeks. Sixty-three patients completed the trial. In both groups flunarizine significantly reduced the frequency and average duration of headache attacks. In group A efficacy was maintained after placebo crossover for the last 4 months of the study. Five subjects in group B stopped placebo because of ineffectiveness; two children in group A discontinued flunarizine treatment, one because of excessive daytime sedation and the other because therapy was ineffective. The main side effects were daytime sedation and weight gain. It is concluded that flunarizine is an effective drug for the treatment of childhood migraine. In a study of this length no serious side effects were discovered.

Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study / F., Sorge; R. D., Simone; E., Marano; M., Nolano; Orefice, Giuseppe; Carrieri, PIETRO BIAGIO. - In: CEPHALALGIA. - ISSN 0333-1024. - ELETTRONICO. - 8:(1988), pp. 1-6.

Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study.

R. D. Simone;OREFICE, GIUSEPPE;CARRIERI, PIETRO BIAGIO
1988

Abstract

An 8-month, double-blind, placebo-controlled, crossover trial of flunarizine in the prophylaxis of migraine has been performed in 70 children. After 4 weeks of medication-free base-line observation, 35 children (group A) received flunarizine (5 mg/day) and 35 (group B) received placebo over a 12-week period. After a 4-week washout they crossed treatments for another 12 weeks. Sixty-three patients completed the trial. In both groups flunarizine significantly reduced the frequency and average duration of headache attacks. In group A efficacy was maintained after placebo crossover for the last 4 months of the study. Five subjects in group B stopped placebo because of ineffectiveness; two children in group A discontinued flunarizine treatment, one because of excessive daytime sedation and the other because therapy was ineffective. The main side effects were daytime sedation and weight gain. It is concluded that flunarizine is an effective drug for the treatment of childhood migraine. In a study of this length no serious side effects were discovered.
1988
Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study / F., Sorge; R. D., Simone; E., Marano; M., Nolano; Orefice, Giuseppe; Carrieri, PIETRO BIAGIO. - In: CEPHALALGIA. - ISSN 0333-1024. - ELETTRONICO. - 8:(1988), pp. 1-6.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/479394
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact