Plakortethers A-G (4-10) represent a new class of plakortin-related metabolites containing a trisubstituted tetrahydrofuran ring. They have been isolated from the Caribbean sponge Plakortis simplex and their stereostructures fully characterized by a combination of spectroscopic data and chemical evidence, based on a three-step conversion of the cycloperoxide plakortin into plakortether B (5). Plakortethers A (4), B (5), D (7), and E (8) exhibited selective cytotoxicity against the RAW 264-7 cell line (murine macrophage).
Plakortethers A-G: A new class of cytotoxic plakortin-derived metabolites / Campagnuolo, C., Fattorusso, E., TAGLIALATELA SCAFATI, O., Ianaro, A., Pisano, B.. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - ELETTRONICO. - 1:(2002), pp. 61-69.
Plakortethers A-G: A new class of cytotoxic plakortin-derived metabolites
TAGLIALATELA SCAFATI, ORAZIO;IANARO, ANGELA;
2002
Abstract
Plakortethers A-G (4-10) represent a new class of plakortin-related metabolites containing a trisubstituted tetrahydrofuran ring. They have been isolated from the Caribbean sponge Plakortis simplex and their stereostructures fully characterized by a combination of spectroscopic data and chemical evidence, based on a three-step conversion of the cycloperoxide plakortin into plakortether B (5). Plakortethers A (4), B (5), D (7), and E (8) exhibited selective cytotoxicity against the RAW 264-7 cell line (murine macrophage).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
