Nociceptin, a novel heptadecapeptide, interacts with ORL1 a G protein-coupled receptor whose sequence is closely related to that of the kappa opioid receptor but has no opioid activity. We have Investigated the conformational preferences of Nociceptin also in comparison to Dynorphin A, The N-terminal part of Nociceptin has the same conformational preferences of She message of endogenous opioids but the C-terminal part of the sequence is more flexible than the corresponding address of Dynorphin A. [Tyr(1)]-Nociceptin, while retaining nociceptive activity, has also an opioid activity comparable to that of enkephalins. (C) 1997 Academic Press.
Solution conformation of nociceptin / S., Salvadori; Picone, Delia; T., Tancredi; R., Guerrini; R., Spadaccini; L. H., Lazarus; D., Regoli; P. A., Temussi. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 233:(1997), pp. 640-643. [10.1006/bbrc.1997.6285]
Solution conformation of nociceptin
PICONE, DELIA;
1997
Abstract
Nociceptin, a novel heptadecapeptide, interacts with ORL1 a G protein-coupled receptor whose sequence is closely related to that of the kappa opioid receptor but has no opioid activity. We have Investigated the conformational preferences of Nociceptin also in comparison to Dynorphin A, The N-terminal part of Nociceptin has the same conformational preferences of She message of endogenous opioids but the C-terminal part of the sequence is more flexible than the corresponding address of Dynorphin A. [Tyr(1)]-Nociceptin, while retaining nociceptive activity, has also an opioid activity comparable to that of enkephalins. (C) 1997 Academic Press.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
