Several tripeptides containing 9-aminofluorene-9-carboxylic acid (Afc), Z-AA1-Afc-AA3-OMe, were synthesized by the modified Ugi reaction using 9-fluorenomimine as a key compound. Several hexapeptides and nonapeptides containing two and there Afc residues, respectively, Z-(AA1-Afc-AA3)n-OMe (n=2-3), could also be synthesized from the above tripeptides. Crystal structures of those tripeptides could be determined by X-ray diffraction. The fluorescence spectra of a hexapeptide showed strong fluorescence quenching in comparison with that of a tripeptide.
Synthesis and Conformation of Peptides Containing 9-Aminofluorene-9-carboxylic Acid / Yamada, T.; Makihira, K.; Yanagihara, R.; Miyazawa, T.; Pavone, Vincenzo; Lombardi, Angelina; De Simone, G.. - In: PEPTIDE SCIENCE. - ISSN 1344-7661. - STAMPA. - (1999), pp. 353-356.
Synthesis and Conformation of Peptides Containing 9-Aminofluorene-9-carboxylic Acid.
PAVONE, VINCENZO;LOMBARDI, ANGELINA;
1999
Abstract
Several tripeptides containing 9-aminofluorene-9-carboxylic acid (Afc), Z-AA1-Afc-AA3-OMe, were synthesized by the modified Ugi reaction using 9-fluorenomimine as a key compound. Several hexapeptides and nonapeptides containing two and there Afc residues, respectively, Z-(AA1-Afc-AA3)n-OMe (n=2-3), could also be synthesized from the above tripeptides. Crystal structures of those tripeptides could be determined by X-ray diffraction. The fluorescence spectra of a hexapeptide showed strong fluorescence quenching in comparison with that of a tripeptide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
