Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano[3,4-g]indole ring system and therefore belong to the same subgroup of Amaryllidaceae alkaloids. In particular, nobilisitine A and B, reported as two new alkaloids, proved to be the 5 beta-hydroxy-3a,11c-epi-masan-7-one and the 3-hydroxybutanoyl ester of clivonine (5 alpha-hydroxy-5a-epi-masan-7-one), the alkaloid previously extracted from Clivia miniata and belonging to the same alkaloid subgroup. Nobilisitine B appears to be an epimer at the acyl side chain of clivatine. (C) 1999 Elsevier Science Ltd. All rights reserved.
Nobilisitine A and B, two masanane-type alkaloids from Clivia nobilis / Evidente, A., A. H., A.D., F. A., D., M. E., A., F. F., K., H. A., M., A., M.. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - STAMPA. - 51:(1999), pp. 1151-1155. [10.1016/S0031-9422(98)00714-6]
Nobilisitine A and B, two masanane-type alkaloids from Clivia nobilis
EVIDENTE, ANTONIO;
1999
Abstract
Two masanane-type lactone alkaloids, named nobilisitine A and B, were isolated from Egyptian Clivia nobilis and characterized by spectroscopic and chemical methods. Both compounds showed contain the same [2]benzopyrano[3,4-g]indole ring system and therefore belong to the same subgroup of Amaryllidaceae alkaloids. In particular, nobilisitine A and B, reported as two new alkaloids, proved to be the 5 beta-hydroxy-3a,11c-epi-masan-7-one and the 3-hydroxybutanoyl ester of clivonine (5 alpha-hydroxy-5a-epi-masan-7-one), the alkaloid previously extracted from Clivia miniata and belonging to the same alkaloid subgroup. Nobilisitine B appears to be an epimer at the acyl side chain of clivatine. (C) 1999 Elsevier Science Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
