Recent studies outlined the role of CAF-1 as a novel useful marker of deregulation of cell proliferation and prognostic indicator in human cancer and preneoplastic lesions. CAF-1 is a heterotrimeric protein complex (constituted by p150, p60 and p48 subunits) that delivers histones H3 and H4 to DNA during DNA replication and DNA repair. Among the three CAF-1 protein subunits, the p60 protein acts mainly on the control of the orderly progression of the cell-cycle. We studied by immunohistochemistry CAF-1 p60 in a selected series of 40 cases of primary SCC of the skin (10 G1, 20 G2, 10 G3). Results have been correlated with those concerning the expression of proliferating cells nuclear antigen (PCNA) and with the main clinico-pathological features of tumors. Our results indicated that CAF-1 p60 may have a role as new prognostic marker in cutaneous SCC.
Chromatin Assembly Factor-1 (CAF-1) loss of function: a role in the deregulation of cellular proliferation in skin squamous cell carcinoma? / Staibano, Stefania; Fabbrocini, Gabriella; Mascolo, Massimo; Salvatore, G; Di Benedetto, M; Mignogna, C; Mezza, E; Capasso, C; Mariano, M; DE ROSA, Gaetano. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - STAMPA. - (2006), pp. 47-47. (Intervento presentato al convegno 3rd Meeting of the European Association of Dermato-Oncology (EADO) tenutosi a Rome nel 23-25 June 2006).
Chromatin Assembly Factor-1 (CAF-1) loss of function: a role in the deregulation of cellular proliferation in skin squamous cell carcinoma?
STAIBANO, STEFANIA;FABBROCINI, GABRIELLA;MASCOLO, MASSIMO;DE ROSA, GAETANO
2006
Abstract
Recent studies outlined the role of CAF-1 as a novel useful marker of deregulation of cell proliferation and prognostic indicator in human cancer and preneoplastic lesions. CAF-1 is a heterotrimeric protein complex (constituted by p150, p60 and p48 subunits) that delivers histones H3 and H4 to DNA during DNA replication and DNA repair. Among the three CAF-1 protein subunits, the p60 protein acts mainly on the control of the orderly progression of the cell-cycle. We studied by immunohistochemistry CAF-1 p60 in a selected series of 40 cases of primary SCC of the skin (10 G1, 20 G2, 10 G3). Results have been correlated with those concerning the expression of proliferating cells nuclear antigen (PCNA) and with the main clinico-pathological features of tumors. Our results indicated that CAF-1 p60 may have a role as new prognostic marker in cutaneous SCC.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
