The distribution of type IV collagenase (cIVase) was evaluated immunohistochemically in a series of normal, dysplastic and neoplastic canine mammary glands, as well as in lymph node metastases. In normal and dysplastic mammary tissues, and benign mammary tumours, cIVase was observed in myoepithelial cells, but in malignant tumours it was mainly localized in the cytoplasm of carcinoma cells and fibroblasts close to infiltrating neoplastic cells. No significant difference was observed between carcinomas of different histological sub-types. These results suggest that the distribution of cIVase is a potentially useful indicator of malignancy in canine mammary tumours. (C) 1997 W.B. Saunders Company Limited.
Immunohistochemical distribution of type IV collagenase in normal, dysplastic and neoplastic canine mammary gland / Papparella, Serenella; Restucci, Brunella; Maiolino, Paola; DE VICO, Gionata. - In: JOURNAL OF COMPARATIVE PATHOLOGY. - ISSN 0021-9975. - ELETTRONICO. - 117:(1997), pp. 277-282. [10.1016/S0021-9975(97)80023-0]
Immunohistochemical distribution of type IV collagenase in normal, dysplastic and neoplastic canine mammary gland
PAPPARELLA, SERENELLA;RESTUCCI, BRUNELLA;MAIOLINO, PAOLA;DE VICO, GIONATA
1997
Abstract
The distribution of type IV collagenase (cIVase) was evaluated immunohistochemically in a series of normal, dysplastic and neoplastic canine mammary glands, as well as in lymph node metastases. In normal and dysplastic mammary tissues, and benign mammary tumours, cIVase was observed in myoepithelial cells, but in malignant tumours it was mainly localized in the cytoplasm of carcinoma cells and fibroblasts close to infiltrating neoplastic cells. No significant difference was observed between carcinomas of different histological sub-types. These results suggest that the distribution of cIVase is a potentially useful indicator of malignancy in canine mammary tumours. (C) 1997 W.B. Saunders Company Limited.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.