1. This paper concerns the study of the effect of L-carnitine on cholesterol metabolism in rat hepatocyte cells BRL-3A. In this research the binding of [I-125]human low density lipoprotein (LDL) to BRL-3A cells and 3-hydroxy 3-methylglutaryl CoA reductase activity (HMG-CoA reductase activity) after L-carnitine incubation were studied. 2. It was found that L-carnitine is able to increase either the [I-125]LDL binding or inhibit the HMG-CoA reductase activity in BRL-3A cells. 3. These results indicate that L-carnitine affects the cholesterol metabolism through an inhibition of HMG-CoA reductase activity that could be responsible for the increased [I-125]LDL binding in rat hepatocytes.
The Effect of L-carnitine On Cholesterol-metabolism In Rat (rattus-bubalus) Hepatocyte Cells / Mondola, Paolo; Santillo, Mariarosaria; R., Demercato; Santangelo, Franco. - In: INTERNATIONAL JOURNAL OF BIOCHEMISTRY. - ISSN 0020-711X. - STAMPA. - 24:(1992), pp. 1047-1050. [10.1016/0020-711X(92)90372-8]
The Effect of L-carnitine On Cholesterol-metabolism In Rat (rattus-bubalus) Hepatocyte Cells
MONDOLA, PAOLO;SANTILLO, MARIAROSARIA;SANTANGELO, FRANCO
1992
Abstract
1. This paper concerns the study of the effect of L-carnitine on cholesterol metabolism in rat hepatocyte cells BRL-3A. In this research the binding of [I-125]human low density lipoprotein (LDL) to BRL-3A cells and 3-hydroxy 3-methylglutaryl CoA reductase activity (HMG-CoA reductase activity) after L-carnitine incubation were studied. 2. It was found that L-carnitine is able to increase either the [I-125]LDL binding or inhibit the HMG-CoA reductase activity in BRL-3A cells. 3. These results indicate that L-carnitine affects the cholesterol metabolism through an inhibition of HMG-CoA reductase activity that could be responsible for the increased [I-125]LDL binding in rat hepatocytes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
