Narciclasine (I), a well known, nonbasic metabolite occurring in some Amaryllidaceae species, possesses an interesting antimitotic activity. It is structurally related to lycorine, the main amaryllidaceae alkaloid, and it exhibits a surprisingly higher activity than lycorine and several of its synthetic and natural analogs in the inhibition of ascorbic acid biosynthesis in potato tuber slices. A previous study on lycorine structure-activity relationships showed that narciclasine had a very strong antibiotic activity when assayed on Corynebacterium fascians.
Narciclasine - H-1-nmr and C-13-nmr Data and A New Improved Method of Preparation / Evidente, Antonio. - In: PLANTA MEDICA. - ISSN 0032-0943. - STAMPA. - 57:(1991), pp. 293-295. [10.1055/s-2006-960098]
Narciclasine - H-1-nmr and C-13-nmr Data and A New Improved Method of Preparation
EVIDENTE, ANTONIO
1991
Abstract
Narciclasine (I), a well known, nonbasic metabolite occurring in some Amaryllidaceae species, possesses an interesting antimitotic activity. It is structurally related to lycorine, the main amaryllidaceae alkaloid, and it exhibits a surprisingly higher activity than lycorine and several of its synthetic and natural analogs in the inhibition of ascorbic acid biosynthesis in potato tuber slices. A previous study on lycorine structure-activity relationships showed that narciclasine had a very strong antibiotic activity when assayed on Corynebacterium fascians.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
