Seven cytochalasins, 17-O-acetylcytochalasin A and two derivatives of cytochalasin B were assayed for Pseudomonas syringae, Bacillus megaterium, and for Geotrichum candidum. Their ability to inhibit the growth of tomato seedlings and their toxicity to brine shrimp (% larvae mortality were also investigated. Among the compounds assayed only cytochalasin A showed antibiotic and fungicidal activity. Toxicity to tomato seedlings was exhibited by both [14]- and [11]-macrocyclic cytochalasans, while the activity decreased in the derivatives acetylated on the 7-hydroxy group and markedly in cytochalasin E. In the brine shrimp bioassay, cytochalasin E was the most active mycotoxin, but generally, at low concentrations, the cytochalasins with the [11]-macrocyclic ring were more active than those with the [14]-macrocyclic ring; cytochalasin A appeared to be the most toxic.
Cytochalasins - Structure-activity-relationships / A., Bottalico; R., Capasso; Evidente, Antonio; G., Randazzo; M., Vurro. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - STAMPA. - 29:(1990), pp. 93-96. [10.1016/0031-9422(90)89018-5]
Cytochalasins - Structure-activity-relationships
EVIDENTE, ANTONIO;
1990
Abstract
Seven cytochalasins, 17-O-acetylcytochalasin A and two derivatives of cytochalasin B were assayed for Pseudomonas syringae, Bacillus megaterium, and for Geotrichum candidum. Their ability to inhibit the growth of tomato seedlings and their toxicity to brine shrimp (% larvae mortality were also investigated. Among the compounds assayed only cytochalasin A showed antibiotic and fungicidal activity. Toxicity to tomato seedlings was exhibited by both [14]- and [11]-macrocyclic cytochalasans, while the activity decreased in the derivatives acetylated on the 7-hydroxy group and markedly in cytochalasin E. In the brine shrimp bioassay, cytochalasin E was the most active mycotoxin, but generally, at low concentrations, the cytochalasins with the [11]-macrocyclic ring were more active than those with the [14]-macrocyclic ring; cytochalasin A appeared to be the most toxic.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.