Vasocortin, a glucocorticoid-induced anti-inflammatory protein, has been purified from the peritoneal lavage fluid of dexamethasone-treated rats. Vasocortin inhibited the release of histamine from rat peritoneal cells stimulated by dextran or concanavalin A but did not alter the release induced by calcium ionophore A23187 or compound 48/80. This selective effect exhibited by vasocortin mimics the glucocorticoid inhibition of histamine release from rat mast cells.
Selective inhibition by vasocortin of histamine release induced by dextran and concanavalin-A from rat peritoneal cells / Carnuccio, Rosa; M., Di Rosa; Ialenti, Armando; Iuvone, Teresa; Sautebin, Lidia. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - STAMPA. - 98:(1989), pp. 32-34.
Selective inhibition by vasocortin of histamine release induced by dextran and concanavalin-A from rat peritoneal cells.
CARNUCCIO, ROSA;IALENTI, ARMANDO;IUVONE, TERESA;SAUTEBIN, LIDIA
1989
Abstract
Vasocortin, a glucocorticoid-induced anti-inflammatory protein, has been purified from the peritoneal lavage fluid of dexamethasone-treated rats. Vasocortin inhibited the release of histamine from rat peritoneal cells stimulated by dextran or concanavalin A but did not alter the release induced by calcium ionophore A23187 or compound 48/80. This selective effect exhibited by vasocortin mimics the glucocorticoid inhibition of histamine release from rat mast cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
