The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin inhibits histamine release from mast cells. Lipocortin and vasocortin may be regarded as the first two identified members of the (perhaps greater) family of glucocorticoid-induced proteins.
Lipocortin and vasocortin: two species of anti-inflammatory proteins mimicking the effects of glucocorticoids / Sautebin, Lidia; Carnuccio, Rosa; Ialenti, Armando; Di Rosa, Massimo. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 25:(1992), pp. 1-12.
Lipocortin and vasocortin: two species of anti-inflammatory proteins mimicking the effects of glucocorticoids.
Lidia Sautebin;Rosa Carnuccio;Armando Ialenti;
1992
Abstract
The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin inhibits histamine release from mast cells. Lipocortin and vasocortin may be regarded as the first two identified members of the (perhaps greater) family of glucocorticoid-induced proteins.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
