In the present study we assessed plasma renin activity (PRA) variations induced by Ca ++ antagonist antihypertensive drug nifedipine in 8 normoreninaemic or hyporeninaemic hypertensive patients. On 2 successive days 3 venous blood samples were sampled, 2 in clinostatic position and the last one 120 min later in orthostatic position; on the second day 20 mg of nifedipine was administered sublingually. Nifedipine significantly increases PRA after orthostatic position compared with starting conditions (p<0.01) and compared with the values recorded without the drug at the same times (p<0.01). Both systolic and diastolic blood pressure decreased 15 and 120 min after nifedipine administration while heart rate increased at the same times. Acute nifedipine administration augments PRA in hypertensive subjects; explanatory hypotheses are proposed.
Changes in plasma renin activity induced by acute administration of nifedipine in hypertensive patients [MODIFICAZIONI DELL'ATTIVITA RENINICA PLASMATICA INDOTTE DALLA SOMMINISTRAZIONE ACUTA DI NIFEDIPINA IN PATIENTI IPERTESI] / Bonaduce, Domenico; Spirito, G; Petretta, Mario; Romano, E; Postiglione, M; Ferrara, Nicola; Rengo, Franco. - In: GIORNALE ITALIANO DI CARDIOLOGIA. - ISSN 0046-5968. - STAMPA. - 9:12(1979), pp. 1452-1455.
Changes in plasma renin activity induced by acute administration of nifedipine in hypertensive patients [MODIFICAZIONI DELL'ATTIVITA RENINICA PLASMATICA INDOTTE DALLA SOMMINISTRAZIONE ACUTA DI NIFEDIPINA IN PATIENTI IPERTESI]
BONADUCE, DOMENICO;PETRETTA, MARIO;FERRARA, NICOLA;RENGO, FRANCO
1979
Abstract
In the present study we assessed plasma renin activity (PRA) variations induced by Ca ++ antagonist antihypertensive drug nifedipine in 8 normoreninaemic or hyporeninaemic hypertensive patients. On 2 successive days 3 venous blood samples were sampled, 2 in clinostatic position and the last one 120 min later in orthostatic position; on the second day 20 mg of nifedipine was administered sublingually. Nifedipine significantly increases PRA after orthostatic position compared with starting conditions (p<0.01) and compared with the values recorded without the drug at the same times (p<0.01). Both systolic and diastolic blood pressure decreased 15 and 120 min after nifedipine administration while heart rate increased at the same times. Acute nifedipine administration augments PRA in hypertensive subjects; explanatory hypotheses are proposed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.