Photochemical behaviour of indomethacin in aqueous media at 254 nm, 310 nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur. (C) 2011 Elsevier B.V. All rights reserved.
Determination of photostability and photodegradation products of indomethacin in aqueous media / Temussi, Fabio; Cermola, Flavio; DELLA GRECA, Marina; Iesce, MARIA ROSARIA; Passananti, Monica; Previtera, Lucio; Zarrelli, Armando. - In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. - ISSN 0731-7085. - 56:4(2011), pp. 678-683. [10.1016/j.jpba.2011.07.005]
Determination of photostability and photodegradation products of indomethacin in aqueous media
TEMUSSI, FABIO;CERMOLA, FLAVIO;DELLA GRECA, MARINA;IESCE, MARIA ROSARIA;PASSANANTI, MONICA;PREVITERA, LUCIO;ZARRELLI, ARMANDO
2011
Abstract
Photochemical behaviour of indomethacin in aqueous media at 254 nm, 310 nm and sunlight was studied by HPLC. The drug exhibited a similar behaviour in all the irradiation experiments affording eight photoproducts that were separated and identified. The main photochemical routes are suggested to proceed via decarboxylation, followed by oxygenation to give an alcohol and an aldehyde and/or by solvent trapping to produce the alcohol. Photoinduced hydrolysis of CO-N bond and oxidative C2-C3 bond breakage also occur. (C) 2011 Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
