The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and antagonist properties, the latter being exhibited at lower concentrations.
1,4-Dihydropyridine activators in the tiamdipine series / Galletti, Ferruccio; Luchowski, E; Triggle, Dj. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 185:(1990), pp. 157-161.
1,4-Dihydropyridine activators in the tiamdipine series.
GALLETTI, FERRUCCIO;
1990
Abstract
The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N-formyl derivative have been measured in rat tail artery, guinea pig ileum and rat heart. The enantiomers of both analogs showed activator and antagonist properties, the latter being exhibited at lower concentrations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
