We have synthesized the CXC chemokine receptor 4(29-39) peptide. This peptides is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Our experiments performed in teh presence of micellar detergents show taht the 1-17 segment of SDF-1 binds CXCR4 (29-39).

A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor 4

PEDONE, CARLO;ROSSI, FILOMENA;BENEDETTI, ETTORE
2003

Abstract

We have synthesized the CXC chemokine receptor 4(29-39) peptide. This peptides is located in the N-terminal region of the receptor and is likely to be involved in the docking step of the receptor interaction with its natural ligand stromal cell-derived factor-1 chemokine, SDF-1. Our experiments performed in teh presence of micellar detergents show taht the 1-17 segment of SDF-1 binds CXCR4 (29-39).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/459372
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