Like cyclosporin A, cyclolinopeptide A binds specifically bovine cyclophilin A, inhibiting its peptidyl-prolyl cis-trans isomerase activity. We describe the protein interaction with several synthetic analogues of cyclolinopeptide A in terms of dissociation and inhibition constants evaluated by fluorescence and inhibition of the enzyme activity.
Specific interaction between cyclophylin A and synthetic analogues of cyclolinopeptide A / Gallo, P.; Rossi, Filomena; Saviano, M.; Pedone, C.; Colonna, G.; Ragone, R.. - In: JOURNAL OF BIOCHEMISTRY. - ISSN 0021-924X. - STAMPA. - 124:(1998), pp. 880-885.
Specific interaction between cyclophylin A and synthetic analogues of cyclolinopeptide A
ROSSI, FILOMENA;
1998
Abstract
Like cyclosporin A, cyclolinopeptide A binds specifically bovine cyclophilin A, inhibiting its peptidyl-prolyl cis-trans isomerase activity. We describe the protein interaction with several synthetic analogues of cyclolinopeptide A in terms of dissociation and inhibition constants evaluated by fluorescence and inhibition of the enzyme activity.File in questo prodotto:
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