Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck region. Tumour thickness, grading and perineural invasion are significant prognostic indicators. However, there is still the need of new reliable biological markers able to predict the prognosis of the single cases with an unfavourable biological behaviour unpredictable by the classic clinical-pathological parameters. 32 cases of (SCC) of the lower lip were analysed for their clincopathologic features, and immunohistochemical expression of Fas/FasL in neoplastic cells and in inflammatory infiltrate. Moreover the density and phenotype of tumour-infiltrating lymphocytes (TIL) were analysed. The results were related with the follow-up of the patients ranging from 2 to 6 years. The cases with over-expression of Fas/FasL in neoplastic cells and Fas+ in T cells preferentially showed a more aggressive clinical behaviour (P<0.01). Moreover we found an alteration of the normal expression of CD4 and CD8 lymphocyte types in ten cases. This data suggest that the Fas/FasL pathway is involved in the close relation between neoplastic cells and T cells and so in the biological behaviour of these tumours.

Squamous cell carcinoma of the lower lip: FAS/FASL expression, lymphocyte subtypes and outcome / Somma, P; Lo Muzio, L; Mansueto, G; Delfino, Mario; Fabbrocini, Gabriella; Mascolo, Massimo; Mignogna, C; Di Benedetto, M; Carinci, F; De Lillo, A; Pastore, L; Serpico, R; DE ROSA, Gaetano; Staibano, Stefania. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 18:1(2005), pp. 59-64.

Squamous cell carcinoma of the lower lip: FAS/FASL expression, lymphocyte subtypes and outcome.

DELFINO, MARIO;FABBROCINI, GABRIELLA;MASCOLO, MASSIMO;DE ROSA, GAETANO;STAIBANO, STEFANIA
2005

Abstract

Squamous cell carcinoma (SCC) of the lip is a relatively common malignancy of the head and neck region. Tumour thickness, grading and perineural invasion are significant prognostic indicators. However, there is still the need of new reliable biological markers able to predict the prognosis of the single cases with an unfavourable biological behaviour unpredictable by the classic clinical-pathological parameters. 32 cases of (SCC) of the lower lip were analysed for their clincopathologic features, and immunohistochemical expression of Fas/FasL in neoplastic cells and in inflammatory infiltrate. Moreover the density and phenotype of tumour-infiltrating lymphocytes (TIL) were analysed. The results were related with the follow-up of the patients ranging from 2 to 6 years. The cases with over-expression of Fas/FasL in neoplastic cells and Fas+ in T cells preferentially showed a more aggressive clinical behaviour (P<0.01). Moreover we found an alteration of the normal expression of CD4 and CD8 lymphocyte types in ten cases. This data suggest that the Fas/FasL pathway is involved in the close relation between neoplastic cells and T cells and so in the biological behaviour of these tumours.
2005
Squamous cell carcinoma of the lower lip: FAS/FASL expression, lymphocyte subtypes and outcome / Somma, P; Lo Muzio, L; Mansueto, G; Delfino, Mario; Fabbrocini, Gabriella; Mascolo, Massimo; Mignogna, C; Di Benedetto, M; Carinci, F; De Lillo, A; Pastore, L; Serpico, R; DE ROSA, Gaetano; Staibano, Stefania. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - 18:1(2005), pp. 59-64.
File in questo prodotto:
File Dimensione Formato  
Squamous cell carcinoma of the lower lip.docx

non disponibili

Tipologia: Abstract
Licenza: Accesso privato/ristretto
Dimensione 14.11 kB
Formato Microsoft Word XML
14.11 kB Microsoft Word XML   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/458213
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 34
social impact