A novel functionalized steroidal BINOL scaffold is produced via a remarkable sequence of dehydrogenation, chlorination and atroposelective phenolic coupling steps. Its formation is straightforwardly obtained in a one-step synthesis under solid state conditions and in the absence of chiral additives.
Atropodiastereoselectivity in solid state BINOL synthesis: Leads from the estradiol platform / Lista, Liliana; Pezzella, Alessandro; Manini, Paola; Napolitano, Alessandra; D'Ischia, Marco. - In: STEROIDS. - ISSN 0039-128X. - 77:6(2012), pp. 630-634. [10.1016/j.steroids.2012.02.007]
Atropodiastereoselectivity in solid state BINOL synthesis: Leads from the estradiol platform
LISTA, LILIANA;PEZZELLA, ALESSANDRO;MANINI, PAOLA;NAPOLITANO, ALESSANDRA;D'ISCHIA, MARCO
2012
Abstract
A novel functionalized steroidal BINOL scaffold is produced via a remarkable sequence of dehydrogenation, chlorination and atroposelective phenolic coupling steps. Its formation is straightforwardly obtained in a one-step synthesis under solid state conditions and in the absence of chiral additives.File in questo prodotto:
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