Abstract Background: Hepatic steatosis (HS) has been associated with obesity and metabolic syndrome (MS), conditions carrying a high risk of coronary artery disease. We aimed to determine whether HS was an independent factor of atherogenic risk beyond its association with MS and its components. Methods: We assessed the circulating levels of the heat shock protein-70 (HSP-70), a chaperone involved in inflammation, endoplasmic reticulum stress and apoptosis at liver and endothelial level and the gamma-glutamyl transferase activity (g-GT) correlating them to carotid intima-media thickness (IMT), along with lipid profile, HOMA, C-reactive protein, fibrinogen, ferritin, adiposity type as well as spleen volume in 52 obese pts with grade 1, 128 with grade 2, and 20 with grade 3 of HS evaluated by sonography. Results: Patients with different grade of HS demonstrated overlapping HSP-70 levels; similarly performed obese subjects regarding IMT. Using multiple regression analysis, IMT was predicted by age, visceral adiposity and by HOMA (b = 0.50, p < 0.0001, b = 0.30, p = 0.01 and b = 0.18, p = 0.048 respectively, while the severity of HS was predicted by visceral and subcutaneous adiposity and HOMA (b = 0.50, p < 0.0001 and b = 0.27, p = 0.001 and b = 0.18, p = 0.024, respectively). Conclusion: In our series of patients with normal or mild elevation of g-GT, the severity of HS does not entail higher IMT, which may be linked to MS stigmata.

ARE HEPATIC STEATOSIS AND CAROTID INTIMA MEDIA THICKNESS ASSOCIATED IN OBESE PATIENTS WITH NORMAL OR SLIGHTLY ELEVATED GAMMA-GLUTAMYL-TRANSFERASE?

TARANTINO, GIOVANNI;COLAO, ANNAMARIA;PASANISI, FABRIZIO;CONTALDO, FRANCO;SCOPACASA, FRANCESCO UMBERTO VITTOR;SAVASTANO, SILVIA
2012

Abstract

Abstract Background: Hepatic steatosis (HS) has been associated with obesity and metabolic syndrome (MS), conditions carrying a high risk of coronary artery disease. We aimed to determine whether HS was an independent factor of atherogenic risk beyond its association with MS and its components. Methods: We assessed the circulating levels of the heat shock protein-70 (HSP-70), a chaperone involved in inflammation, endoplasmic reticulum stress and apoptosis at liver and endothelial level and the gamma-glutamyl transferase activity (g-GT) correlating them to carotid intima-media thickness (IMT), along with lipid profile, HOMA, C-reactive protein, fibrinogen, ferritin, adiposity type as well as spleen volume in 52 obese pts with grade 1, 128 with grade 2, and 20 with grade 3 of HS evaluated by sonography. Results: Patients with different grade of HS demonstrated overlapping HSP-70 levels; similarly performed obese subjects regarding IMT. Using multiple regression analysis, IMT was predicted by age, visceral adiposity and by HOMA (b = 0.50, p < 0.0001, b = 0.30, p = 0.01 and b = 0.18, p = 0.048 respectively, while the severity of HS was predicted by visceral and subcutaneous adiposity and HOMA (b = 0.50, p < 0.0001 and b = 0.27, p = 0.001 and b = 0.18, p = 0.024, respectively). Conclusion: In our series of patients with normal or mild elevation of g-GT, the severity of HS does not entail higher IMT, which may be linked to MS stigmata.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/456809
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