We present an autoradiography system (BETAview) for a quantitative analysis of radioactive markers in biological samples; this system is also able to monitor a dynamic process. It is based on a solid-state pixel array detector, bump bonded to low threshold, integrated electronics developed for medical applications (Medipix). The present assembly is equipped with a 200 um thick GaAs square detector, about 1cm side, segmented into 64x64 170-um size square pixels; simulation and experimental studies show good linearity and high sensitivity to b sources. Imaging tests with beta sources of medical and biological interest such as 14C, 35S, 32P are reported.
GaAs pixel arrays for β imaging in medicine and biology / L., Abate; Bertolucci, Ennio; Conti, Maurizio; Mettivier, Giovanni; Montesi, MARIA CRISTINA; Russo, Paolo. - In: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. - ISSN 0168-9002. - 460:(2001), pp. 97-106. [10.1016/S0168-9002(00)01102-5]
GaAs pixel arrays for β imaging in medicine and biology
BERTOLUCCI, ENNIO;CONTI, MAURIZIO;METTIVIER, GIOVANNI;MONTESI, MARIA CRISTINA;RUSSO, PAOLO
2001
Abstract
We present an autoradiography system (BETAview) for a quantitative analysis of radioactive markers in biological samples; this system is also able to monitor a dynamic process. It is based on a solid-state pixel array detector, bump bonded to low threshold, integrated electronics developed for medical applications (Medipix). The present assembly is equipped with a 200 um thick GaAs square detector, about 1cm side, segmented into 64x64 170-um size square pixels; simulation and experimental studies show good linearity and high sensitivity to b sources. Imaging tests with beta sources of medical and biological interest such as 14C, 35S, 32P are reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
