Enzymic oxidn. of 5-cystein-S-yldopa (I) leads to a complex mixt. of oligomeric products, 2 of which were isolated by preparative HPLC and identified as diastereomers corresponding to the gross structure (II). Under acidic conditions, both compds. are rapidly converted into trichochrome F (III), a Δ2,2'-bi-(2H-1,4-benzothiazine) pigment previously isolated by extn. of red hair and feathers.
New intermediates of pheomelanogenesis in vitro beyond the 1,4-benzothiazine stage / C., Costantini; Crescenzi, Orlando; Prota, Giuseppe; A., Palumbo. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 46:19(1990), pp. 6831-6838. [10.1016/S0040-4020(01)87870-4]
New intermediates of pheomelanogenesis in vitro beyond the 1,4-benzothiazine stage
CRESCENZI, ORLANDO;PROTA, GIUSEPPE;
1990
Abstract
Enzymic oxidn. of 5-cystein-S-yldopa (I) leads to a complex mixt. of oligomeric products, 2 of which were isolated by preparative HPLC and identified as diastereomers corresponding to the gross structure (II). Under acidic conditions, both compds. are rapidly converted into trichochrome F (III), a Δ2,2'-bi-(2H-1,4-benzothiazine) pigment previously isolated by extn. of red hair and feathers.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
