Solid-state NMR spectroscopy was applied to the analysis of melanins prepared by peroxidase-H2O2 oxidation of dopamines specifically C-13 labelled in the alpha- or beta-side chain positions. A surprisingly diverse pattern of signals indicated the presence of uncyclized dopamine and noradrenaline-derived units, in addition to indole and carbonyl carbon atoms. These structural features, coupled with the results obtained from elemental analysis of dopamine melanin samples prepared under different conditions, point to a pigment formation process more complex than previously believed
Synthesis of dopamines labeled with 13C in the alpha- or beta-side chain position and their application to structural studies on melanins by solid-state NMR spectroscopy / Crescenzi, Orlando; C., Kroesche; W., Hoffbauer; M., Jansen; Napolitano, Alessandra; Prota, Giuseppe; M. G., Peter. - In: LIEBIGS ANNALEN DER CHEMIE. - ISSN 0170-2041. - STAMPA. - 6(1994), pp. 563-567. [10.1002/jlac.199419940606]
Synthesis of dopamines labeled with 13C in the alpha- or beta-side chain position and their application to structural studies on melanins by solid-state NMR spectroscopy
CRESCENZI, ORLANDO;NAPOLITANO, ALESSANDRA;PROTA, GIUSEPPE;
1994
Abstract
Solid-state NMR spectroscopy was applied to the analysis of melanins prepared by peroxidase-H2O2 oxidation of dopamines specifically C-13 labelled in the alpha- or beta-side chain positions. A surprisingly diverse pattern of signals indicated the presence of uncyclized dopamine and noradrenaline-derived units, in addition to indole and carbonyl carbon atoms. These structural features, coupled with the results obtained from elemental analysis of dopamine melanin samples prepared under different conditions, point to a pigment formation process more complex than previously believedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
