The measurement of glucose utilization rate(GUR) by positron emission tomography (PET) using18F-2-fuoro-2-deoxy-D-glucose (FDG) is a valuable method to assess the grade of malignancy brain tumors We have designed a feasibility trial to determine whether PET could be used to image and predict the grade of malignancy of human extremity muskuloskelatl tumors . Five patients with extremity tumors (four soft-tissue tumors and one osteogenic tumor)were studied. Peak and mean apparent GUR were determined in the tumor region. All tumors were subsequently resected and graded in a standard fashion using the NCI grading system Peak apparent GUR ranged from 3.3 mg/100mg/min to 15.2mg/100/min with the highest values found in the high grade tumors. Although the number of patients studied was small, a good correspondence was shown between GURs and histopathologic grading. Our results indicate that PET can be used to image and evaluate the metabolic activity of human musculoskeletal tumors.
Metabolic imaging of human extremity musculoskeletal tumors by PET / Kern, K.a., Brunetti, A., Norton, J.a., Chang, A.e., Malawer, M., Lack, E., Finn, R.d., Rosenberg, S.a., Larson, S.m.. - In: THE JOURNAL OF NUCLEAR MEDICINE. - ISSN 0161-5505. - STAMPA. - 29:(1988), pp. 181-186.
Metabolic imaging of human extremity musculoskeletal tumors by PET.
BRUNETTI, ARTURO;
1988
Abstract
The measurement of glucose utilization rate(GUR) by positron emission tomography (PET) using18F-2-fuoro-2-deoxy-D-glucose (FDG) is a valuable method to assess the grade of malignancy brain tumors We have designed a feasibility trial to determine whether PET could be used to image and predict the grade of malignancy of human extremity muskuloskelatl tumors . Five patients with extremity tumors (four soft-tissue tumors and one osteogenic tumor)were studied. Peak and mean apparent GUR were determined in the tumor region. All tumors were subsequently resected and graded in a standard fashion using the NCI grading system Peak apparent GUR ranged from 3.3 mg/100mg/min to 15.2mg/100/min with the highest values found in the high grade tumors. Although the number of patients studied was small, a good correspondence was shown between GURs and histopathologic grading. Our results indicate that PET can be used to image and evaluate the metabolic activity of human musculoskeletal tumors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
