Four patients with human-immuno-deficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.
Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine / Yarchoan, R., Berg, G., Brouwers, P., Fischl, M.a., Spitzer, A.r., Wichman, A., Grafman, J., Thomas, R.v., Safai, B., Brunetti, A.. - In: THE LANCET. - ISSN 0140-6736. - STAMPA. - 1:8525(1987), pp. 132-135.
Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine.
BRUNETTI, ARTURO
1987
Abstract
Four patients with human-immuno-deficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
