A NMR structural study of quadruplex [d(TGGGT)]4 containing a modified thymine is reported. The three dimensional structure of the complex is very similar to those of other parallel stranded quadruplexes. The modified thymines (T*) are able, at least in the minimised structures, to form a tetrad containing extra H-bonds through the hydroxyl groups. Nevertheless, in this new tetrad the modified thymines are slightly open towards the solvent respect to the unmodified T-tetrad.
1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine / Petraccone, Luigi; Erra, Eva; Lucia, Nasti; Galeone, Aldo; Randazzo, Antonio; Esposito, Veronica; Mayol, Luciano; Barone, Guido; Giancola, Concetta. - In: NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS. - ISSN 1525-7770. - STAMPA. - (2003), pp. 1677-1680.
1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine
PETRACCONE, LUIGI;ERRA, EVA;GALEONE, ALDO;RANDAZZO, ANTONIO;ESPOSITO, VERONICA;MAYOL, LUCIANO;BARONE, GUIDO;GIANCOLA, CONCETTA
2003
Abstract
A NMR structural study of quadruplex [d(TGGGT)]4 containing a modified thymine is reported. The three dimensional structure of the complex is very similar to those of other parallel stranded quadruplexes. The modified thymines (T*) are able, at least in the minimised structures, to form a tetrad containing extra H-bonds through the hydroxyl groups. Nevertheless, in this new tetrad the modified thymines are slightly open towards the solvent respect to the unmodified T-tetrad.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
