A NMR structural study of quadruplex [d(TGGGT)]4 containing a modified thymine is reported. The three dimensional structure of the complex is very similar to those of other parallel stranded quadruplexes. The modified thymines (T*) are able, at least in the minimised structures, to form a tetrad containing extra H-bonds through the hydroxyl groups. Nevertheless, in this new tetrad the modified thymines are slightly open towards the solvent respect to the unmodified T-tetrad.

1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine

PETRACCONE, LUIGI;ERRA, EVA;GALEONE, ALDO;RANDAZZO, ANTONIO;ESPOSITO, VERONICA;MAYOL, LUCIANO;BARONE, GUIDO;GIANCOLA, CONCETTA
2003

Abstract

A NMR structural study of quadruplex [d(TGGGT)]4 containing a modified thymine is reported. The three dimensional structure of the complex is very similar to those of other parallel stranded quadruplexes. The modified thymines (T*) are able, at least in the minimised structures, to form a tetrad containing extra H-bonds through the hydroxyl groups. Nevertheless, in this new tetrad the modified thymines are slightly open towards the solvent respect to the unmodified T-tetrad.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11588/4559
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