We have identified a novel role for Pin1 as a modulator of CD8+ cDC development. Consistent with reduced numbers of CD8+ cDC in Pin1-null mice, we find that the absence of Pin1 impairs CD8+ T cell proliferation in response to infection with Listeria monocytogenes. These data suggest that, via regulation of CD8+ cDC production, Pin1 may serve as an important modulator of adaptive immunity.
The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice / Barberi, Tj; Dunkle, A; He, Yw; Racioppi, Luigi; Means, Ar. - In: PLOS ONE. - ISSN 1932-6203. - 7:1(2012), pp. e29808-e29816. [10.1371/journal.pone.0029808]
The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice.
RACIOPPI, LUIGI;
2012
Abstract
We have identified a novel role for Pin1 as a modulator of CD8+ cDC development. Consistent with reduced numbers of CD8+ cDC in Pin1-null mice, we find that the absence of Pin1 impairs CD8+ T cell proliferation in response to infection with Listeria monocytogenes. These data suggest that, via regulation of CD8+ cDC production, Pin1 may serve as an important modulator of adaptive immunity.File in questo prodotto:
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