Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two new alkaloids, named sinulasulfoxide (1) and sinulasulfone (2), characterized by an amide linkage between a phytanic acid moiety and an uncommon sulfur-containing unit. Their complete stereostructures were elucidated by interpretation of MS and NMR data along with CD analysis and chemical modifications. Sinulasulfoxide (1) proved to moderately inhibit LPS-induced NO release.
Sinulasulfoxide and sinulasulfone, sulfur-containing alkaloids from the Indonesian soft coral Sinularia sp / Putra, M. Y.; Ianaro, Angela; Panza, Elisabetta; Bavestrello, G; Cerrano, C; Fattorusso, Ernesto; TAGLIALATELA SCAFATI, Orazio. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 53:(2012), pp. 3937-3939. [10.1016/j.tetlet.2012.05.095]
Sinulasulfoxide and sinulasulfone, sulfur-containing alkaloids from the Indonesian soft coral Sinularia sp.
IANARO, ANGELA;PANZA, ELISABETTA;FATTORUSSO, ERNESTO;TAGLIALATELA SCAFATI, ORAZIO
2012
Abstract
Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two new alkaloids, named sinulasulfoxide (1) and sinulasulfone (2), characterized by an amide linkage between a phytanic acid moiety and an uncommon sulfur-containing unit. Their complete stereostructures were elucidated by interpretation of MS and NMR data along with CD analysis and chemical modifications. Sinulasulfoxide (1) proved to moderately inhibit LPS-induced NO release.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
