A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
Ruthenium-based complex nanocarriers forcancer therapy / Mangiapia, Gaetano; D'Errico, Gerardino; Simeone, Luca; Irace, Carlo; A., Radulescu; DI PASCALE, Antonio; Colonna, Alfredo; Montesarchio, Daniela; Paduano, Luigi. - In: BIOMATERIALS. - ISSN 0142-9612. - 33:14(2012), pp. 3770-3782. [10.1016/j.biomaterials.2012.01.057]
Ruthenium-based complex nanocarriers forcancer therapy
MANGIAPIA, GAETANO;D'ERRICO, GERARDINO;SIMEONE, LUCA;IRACE, CARLO;DI PASCALE, ANTONIO;COLONNA, ALFREDO;MONTESARCHIO, DANIELA;PADUANO, LUIGI
2012
Abstract
A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
