An amphiphilic ruthenium-based mol. (DOPURu) with potential antineoplastic activity has been synthesized, and its aggregation behavior in the presence of phospholipids has been investigated. A very rich variety of aggregates has been found, spanning from vesicles to cubic bicontinuous phases. Cubosomes here presented represent one of the first systems with potential use for medical therapy.
Cubosomes for ruthenium complex delivery: formulation and characterization / Mangiapia, Gaetano; M., Vaccaro; D'Errico, Gerardino; A., Radulescu; H., Frielinghaus; V., Pipich; A. M., Carnerup; Paduano, Luigi. - In: SOFT MATTER. - ISSN 1744-683X. - 7:(2011), pp. 10577-10580. [10.1039/c1sm06323e]
Cubosomes for ruthenium complex delivery: formulation and characterization
MANGIAPIA, GAETANO;D'ERRICO, GERARDINO;PADUANO, LUIGI
2011
Abstract
An amphiphilic ruthenium-based mol. (DOPURu) with potential antineoplastic activity has been synthesized, and its aggregation behavior in the presence of phospholipids has been investigated. A very rich variety of aggregates has been found, spanning from vesicles to cubic bicontinuous phases. Cubosomes here presented represent one of the first systems with potential use for medical therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
