β-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the β-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive β-hairpin peptides
β-Hairpin stabilization through an interstrand triazole bridge / Celentano, V.; Diana, D.; DE ROSA, Lucia; Romanelli, Alessandra; Fattorusso, R.; D'Andrea, L. D.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 48:5(2012), pp. 762-764. [10.1039/C1CC16017F]
β-Hairpin stabilization through an interstrand triazole bridge
D. Diana;DE ROSA, LUCIA;ROMANELLI, ALESSANDRA;
2012
Abstract
β-Hairpin peptides were conformationally stabilized through a 1,4 disubstituted 1,2,3-triazole interstrand linkage. A NMR conformational analysis revealed that the β-hairpin content depends on the number and position of substituent methylene units of the 1,2,3-triazole ring. These results will allow the design of metabolically stable peptidomimetic analogs of bioactive β-hairpin peptidesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
