The present invention relates to a method for the diagnosis and prognosis of the systemic sclerosis, and for discriminating between Raynaud phenomenon and systemic sclerosis, based on the presence of IgG auto-antibodies directed to the PDGF receptor (PDGFR) in systemic sclerosis patients. Therefore it is an object of the invention an in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor by incubating the body sample with an effective amount of a specific ligand for such auto-antibodies in conditions allowing the binding and the formation of a complex and detecting the bound auto-antibodies, or the complex, if present. It is another object of the invention a diagnostic kit for the method described.
Stimulatory auto-antibodies to the pdgf receptor as pathology marker and therapeutic target / Avvedimento, VITTORIO ENRICO; Gabrielli, A.; Svegliati, S.; Funaro, A.; Santillo, Mariarosaria; Paterno', Roberto; Moroncini, G.; Lucchetti, M.. - (2007).
Stimulatory auto-antibodies to the pdgf receptor as pathology marker and therapeutic target
AVVEDIMENTO, VITTORIO ENRICO;SANTILLO, MARIAROSARIA;PATERNO', ROBERTO;
2007
Abstract
The present invention relates to a method for the diagnosis and prognosis of the systemic sclerosis, and for discriminating between Raynaud phenomenon and systemic sclerosis, based on the presence of IgG auto-antibodies directed to the PDGF receptor (PDGFR) in systemic sclerosis patients. Therefore it is an object of the invention an in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor by incubating the body sample with an effective amount of a specific ligand for such auto-antibodies in conditions allowing the binding and the formation of a complex and detecting the bound auto-antibodies, or the complex, if present. It is another object of the invention a diagnostic kit for the method described.| File | Dimensione | Formato | |
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Aggiunta Paternò come inventore Brevetto Rilasciato in Europa 1907851.pdf
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Brevetto Rilasciato in Europa 1907851. Stimulatory autoantibodies to the PDGF......pdf
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