Oligonucleotides with a 3'-3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes.
Oligonucleotides containing a lysine residue as 3’-3’ junction for alternate strand triple helix formation / Barone, Guido; DE NAPOLI, Lorenzo; DI FABIO, Giovanni; Giancola, Concetta; A., Messere; Montesarchio, Daniela; Petraccone, Luigi; Piccialli, Gennaro. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 9:11(2001), pp. 2895-2900. [10.1016/S0968-0896(01)00164-X]
Oligonucleotides containing a lysine residue as 3’-3’ junction for alternate strand triple helix formation
BARONE, GUIDO;DE NAPOLI, LORENZO;DI FABIO, GIOVANNI;GIANCOLA, CONCETTA;MONTESARCHIO, DANIELA;PETRACCONE, LUIGI;PICCIALLI, GENNARO
2001
Abstract
Oligonucleotides with a 3'-3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
