Three saponins, named minutoside A (1), minutoside B (2), minutoside C (3), and two known sapogenins, alliogenin and neoagigenin, were isolated from the bulbs of Allium minutiflorum Regel. Elucidation of their structure was carried out by comprehensive spectroscopic analyses, including 2D NMR spectroscopy and mass spectrometry. The structures of the new compounds were identified as (25R)-furost-2 alpha,3 beta,6 beta,22 alpha,26-pentaol 3-O-[beta-D-Xyl0pYranosyl-(1 -> 3)-O-beta-D-glucopyranosyl-(14)-O-beta-D-galactopyranosyl] 26-O-beta-D-glucopyranoside (1), (25S)-spirostan-2 alpha,3,60-triol 3-O-beta-D-xylopyranosyl-(1 -> 3)-O-beta-D-glucopyranosyl-(1 -> 4)-O-D-D-galactopyranoside (2), and (25R)-furost-2 alpha,3 beta,5 alpha,6 beta,22 alpha,26-esaol 3-O-[beta-D-xylopyranosyl-(1 -> 3)-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-galactopyranosyl] 26-O-beta-D-glucopyranoside (3). The isolated compounds were evaluated for their antimicrobial activity. All the novel saponins showed a significant antifungal activity depending on their concentration and with the following rank: minutoside B > minutoside C >> minutoside A. No appreciable antibacterial activity was recorded. The possible role of these saponins in plant-microbe interactions is discussed. (c) 2006 Elsevier Ltd. All rights reserved.
Saponins from Allium minutiflorum with antifungal activity / E., Barile; Bonanomi, Giuliano; V., Antignani; B., Zolfaghari; S. E., Sajjadi; Scala, Felice; Lanzotti, Virginia. - In: PHYTOCHEMISTRY. - ISSN 0031-9422. - ELETTRONICO. - 68:(2007), pp. 596-603. [10.1016/j.phytochem.2006.10.009]
Saponins from Allium minutiflorum with antifungal activity
BONANOMI, GIULIANO;SCALA, FELICE;LANZOTTI, VIRGINIA
2007
Abstract
Three saponins, named minutoside A (1), minutoside B (2), minutoside C (3), and two known sapogenins, alliogenin and neoagigenin, were isolated from the bulbs of Allium minutiflorum Regel. Elucidation of their structure was carried out by comprehensive spectroscopic analyses, including 2D NMR spectroscopy and mass spectrometry. The structures of the new compounds were identified as (25R)-furost-2 alpha,3 beta,6 beta,22 alpha,26-pentaol 3-O-[beta-D-Xyl0pYranosyl-(1 -> 3)-O-beta-D-glucopyranosyl-(14)-O-beta-D-galactopyranosyl] 26-O-beta-D-glucopyranoside (1), (25S)-spirostan-2 alpha,3,60-triol 3-O-beta-D-xylopyranosyl-(1 -> 3)-O-beta-D-glucopyranosyl-(1 -> 4)-O-D-D-galactopyranoside (2), and (25R)-furost-2 alpha,3 beta,5 alpha,6 beta,22 alpha,26-esaol 3-O-[beta-D-xylopyranosyl-(1 -> 3)-O-beta-D-glucopyranosyl-(1 -> 4)-O-beta-D-galactopyranosyl] 26-O-beta-D-glucopyranoside (3). The isolated compounds were evaluated for their antimicrobial activity. All the novel saponins showed a significant antifungal activity depending on their concentration and with the following rank: minutoside B > minutoside C >> minutoside A. No appreciable antibacterial activity was recorded. The possible role of these saponins in plant-microbe interactions is discussed. (c) 2006 Elsevier Ltd. All rights reserved.File | Dimensione | Formato | |
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