A new bioactive sesquiterpenoid, named dysidotronic acid (I), with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone. The chem. structure of I was detd. on the basis of spectroscopic data. Dysidotronic acid (I) significantly inhibited human synovial phospholipase A2 (PLA2) at 10 mM, with an IC50 value of 2.6 mM and a higher selectivity and potency towards this enzyme than the ref. inhibitor manoalide.
Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp / Giannini, C.; Debitus, C.; Posadas, I.; Paya, M.; D'Auria, MARIA VALERIA. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 41:(2000), pp. 3257-3260.
Dysidotronic acid, a new and selective human phospholipase A2 inhibitor from the sponge Dysidea sp.
D'AURIA, MARIA VALERIA
2000
Abstract
A new bioactive sesquiterpenoid, named dysidotronic acid (I), with a rearranged drimane skeleton has been isolated from the sponge Dysidea sp. from Vanuatu islands, along with bolinaquinone. The chem. structure of I was detd. on the basis of spectroscopic data. Dysidotronic acid (I) significantly inhibited human synovial phospholipase A2 (PLA2) at 10 mM, with an IC50 value of 2.6 mM and a higher selectivity and potency towards this enzyme than the ref. inhibitor manoalide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
