he synthesis of beta-Gal-(1 -> 3)-alpha-GalNAc-(1 -> 3)-beta-GalNAc allyl trisaccharide as the outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide was accomplished through a concise, optimized, multi-step synthesis, having as key steps three glycosylations, that were in-depth studied performing them under several conditions. The target trisaccharide was designed with an allyl aglycone in order to open a future access to the conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against this Burkholderia pathogen.
Synthesis of the trisaccharide outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide / Bedini, Emiliano; Cirillo, L.; Parrilli, Michelangelo. - In: CARBOHYDRATE RESEARCH. - ISSN 0008-6215. - 349:(2012), pp. 24-32. [10.1016/j.carres.2011.12.007]
Synthesis of the trisaccharide outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide
BEDINI, EMILIANO;PARRILLI, MICHELANGELO
2012
Abstract
he synthesis of beta-Gal-(1 -> 3)-alpha-GalNAc-(1 -> 3)-beta-GalNAc allyl trisaccharide as the outer core fragment of Burkholderia cepacia pv. vietnamiensis lipooligosaccharide was accomplished through a concise, optimized, multi-step synthesis, having as key steps three glycosylations, that were in-depth studied performing them under several conditions. The target trisaccharide was designed with an allyl aglycone in order to open a future access to the conjugation with an immunogenic protein en route to the development of a synthetic neoglycoconjugate vaccine against this Burkholderia pathogen.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
